Asthma: How a Novel Approach Could Improve the Effectiveness of Existing Medications?
April 17, 2023
Asthma is a chronic respiratory disease that affects millions of individuals throughout the world. While there are effective asthma drugs available, not all individuals respond equally to these therapies. Researchers are always seeking for innovative ways to increase the efficacy of existing asthma treatments. In this article, we will look at an innovative way to treating asthma that may increase the efficacy of current drugs.
Asthma affects the lungs' airways. Asthmatics cause the airways to become inflamed and narrow, making breathing difficult. Wheezing, coughing, shortness of breath, and chest tightness are all symptoms of asthma. Allergens, exertion, stress, and pollution are all potential triggers for asthma episodes.
Inhaled corticosteroids, long-acting beta-agonists, leukotriene modifiers, and mast cell stabilisers are among the drugs available to treat asthma. These drugs operate by reducing inflammation in the airways and relaxing the muscles that surround the airways, making breathing easier.
While these drugs can help with asthma symptoms, they do not work for everyone. Some people may also develop adverse effects such as throat discomfort, hoarseness, and an increased risk of infection.
An Innovative Approach to Asthma Treatment
Researchers are investigating a potential asthma treatment strategy that involves targeting a specific type of immune cell in the lungs known as group 2 innate lymphoid cells (ILC2s). ILC2s are important players in the inflammatory response that underlies asthma symptoms.
Researchers want to minimise inflammation in the airways and increase the efficacy of existing asthma treatments by targeting ILC2s. The use of monoclonal antibodies, which are laboratory-made proteins that imitate the immune system's ability to fight off dangerous viruses, is one strategy being investigated.
Monoclonal antibodies can be programmed to target certain cells or substances in the immune system. Researchers seek to minimise inflammation in the airways and improve asthma symptoms by targeting ILC2s with monoclonal antibodies.
Several clinical trials are now underway to assess the efficacy of monoclonal antibodies in the treatment of asthma. The DREAMM research, for example, is testing the efficacy of a monoclonal antibody called tezepelumab in lowering asthma exacerbations.
The DREAMM study's preliminary findings have proven promising. Tezepelumab was reported to significantly reduce asthma exacerbations and improve lung function compared to placebo in a phase 2 trial including approximately 500 patients with severe asthma.
Another study published in The Lancet Respiratory Medicine looked at the efficacy of dupilumab, a monoclonal antibody, in treating asthma. When compared to placebo, those who got dupilumab showed a significant reduction in asthma exacerbations and better lung function.
Not all patients respond equally to these medications. Researchers are investigating a potential asthma treatment strategy that involves targeting a specific type of immune cell in the lungs known as group 2 innate lymphoid cells (ILC2s). Researchers want to minimise inflammation in the airways and increase the efficacy of existing asthma treatments by targeting ILC2s using monoclonal antibodies. While this method is still in its early phases of development, it has the potential to improve asthma control while lowering the risk of adverse effects associated with current treatments.
Some asthma management options include:
Identifying and avoiding triggers: Allergens, exercise, stress, and pollution are common asthma triggers. Patients can lower their risk of asthma attacks by recognising and avoiding triggers.
Taking drugs as directed: It is critical to take asthma medications as directed, even if symptoms are under control. Skipping doses or discontinuing drugs without visiting a physician can raise the risk of asthma attacks.
Monitoring symptoms: Asthmatic patients should keep a close eye on their symptoms and seek medical assistance if they worsen or do not improve with medication.
Maintaining a healthy lifestyle: Eating a balanced diet, exercising regularly, and managing stress can all help to improve general health and minimise the chance of asthma episodes.
Asthma can sometimes be highly complicated to control. While there are effective asthma drugs available, not all individuals respond equally to these therapies. Researchers are investigating a potential asthma treatment strategy that involves targeting a specific type of immune cell in the lungs known as group 2 innate lymphoid cells (ILC2s).
Researchers want to increase the effectiveness of existing asthma treatments and lower the risk of adverse effects by targeting ILC2s using monoclonal antibodies. In the interim, persons with asthma can work with a healthcare professional to build an asthma management plan that includes the right drugs and techniques for avoiding triggers.
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